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Sphincter of Oddi dysfunction

G A Lehman1, S Sherman

  • 1Department of Medicine, Indiana University Medical Center, Indianapolis 46202-5000, USA. glenl@medicine.dmed.iupui.edu

International Journal of Pancreatology : Official Journal of the International Association of Pancreatology
|August 1, 1996
PubMed
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Sphincter of Oddi dysfunction can cause abdominal pain, pancreatitis, and cholestasis. Treatment options range from medical therapy to invasive sphincter ablation, with careful consideration of risks and benefits.

Area of Science:

  • Gastroenterology
  • Hepatology
  • Surgical Gastroenterology

Background:

  • Sphincter of Oddi dysfunction (SOD) is increasingly recognized as a cause of biliary and pancreatic disorders.
  • Symptoms include recurrent abdominal pain, pancreatitis, and cholestasis.
  • Accurate diagnosis and effective management remain challenging.

Purpose of the Study:

  • To review the current understanding of sphincter of Oddi dysfunction.
  • To discuss diagnostic approaches, including noninvasive tests and manometry.
  • To outline therapeutic strategies, including medical management and endoscopic or surgical interventions.

Main Methods:

  • Review of existing literature on sphincter of Oddi dysfunction.
  • Analysis of diagnostic criteria and their limitations.

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  • Evaluation of treatment outcomes and complication rates.

    • Main Results:

    • Sphincter of Oddi dysfunction is associated with significant morbidity.
    • Noninvasive tests can suggest SOD, while manometry offers precise diagnosis.
    • Both biliary and pancreatic sphincters are frequently implicated.
    • Sphincter ablation is an option for refractory cases, but carries risks.

    Conclusions:

    • Early diagnosis and appropriate management of SOD are crucial.
    • Risk-benefit assessment is vital when considering invasive procedures.
    • Further research is needed to elucidate etiology, pathophysiology, and optimize therapies.