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Hypertension optimal treatment: the Israeli HOT Study Group. Hypertension Optimal Treatment

T Rosenthal1

  • 1Chorley Institute of Hypertension, Chaim Sheba Medical Center, Israel.

Journal of Human Hypertension
|September 1, 1996
PubMed

Insights

The Hypertension Optimal Treatment (HOT) Study found felodipine effective for managing hypertension. Most Israeli patients tolerated the treatment well, enabling continued use in this hypertensive cohort.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Trials

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Effective blood pressure control is crucial for reducing morbidity and mortality.
  • The Hypertension Optimal Treatment (HOT) Study investigated different diastolic blood pressure targets.

Purpose of the Study:

  • To assess the cardiovascular effects of three target diastolic blood pressure levels (< 90, < 85, and < 80 mm Hg) in hypertensive patients.
  • To evaluate the efficacy and tolerability of felodipine treatment in the Israeli cohort of the HOT Study.
  • To compare treatment patterns in the Israeli cohort with the global HOT Study population.

Main Methods:

  • Recruitment of 411 patients in the Israeli cohort of the multinational HOT Study.
  • Initial treatment with felodipine, supplemented with other antihypertensive drugs as needed.
  • Comparison of treatment outcomes and drug dosages between Israeli patients and those from other countries.

Main Results:

  • Israeli patients had a higher rate of prior antihypertensive treatment, indicating a more complex patient profile.
  • A lower percentage of Israeli patients received low-dose felodipine (50% vs. 56% globally).
  • A higher percentage of Israeli patients required high-dose felodipine plus additional medications (3.8% vs. 2.9% globally).
  • Felodipine demonstrated good tolerability, allowing most patients to continue the regimen.

Conclusions:

  • Felodipine is well-tolerated and effective in managing hypertension in the Israeli cohort.
  • Treatment strategies were adjusted in Israeli patients due to higher prevalence of prior treatments.
  • The HOT Study provides valuable insights into optimizing antihypertensive therapy for diverse patient populations.

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