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Summary
Primary hypothyroidism in children presents distinct sellar configurations on skull films. The "cherry" sella in older children indicates reversible pituitary enlargement, while younger children show immature, "bowl-like" sellas.
Area of Science:
- Pediatric Endocrinology
- Radiology
- Skeletal Biology
Background:
- Primary hypothyroidism in children can manifest with characteristic sellar (pituitary fossa) changes.
- These sellar configurations may offer diagnostic clues on lateral skull radiographs.
Purpose of the Study:
- To describe and differentiate sellar configurations associated with primary childhood hypothyroidism.
- To evaluate the diagnostic utility of these sellar findings in identifying hypothyroidism.
Main Methods:
- Retrospective analysis of lateral skull films from children diagnosed with primary hypothyroidism.
- Correlation of sellar morphology with patient age and clinical presentation.
Main Results:
- Two distinct sellar patterns were observed: a round, enlarged "cherry" sella in older children, and an immature, "bowl-like" sella in infants and young children.
- The "cherry" sella is attributed to reversible pituitary gland hypertrophy and is associated with early, adequate treatment.
Conclusions:
- Sellar morphology on lateral skull films can suggest a diagnosis of primary hypothyroidism in children.
- The "cherry" sella is a particularly characteristic finding in older children with this condition.