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Rodent parvovirus infections
R O Jacoby1, L J Ball-Goodrich, D G Besselsen
1Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Abstract:
Parvoviruses are among the most common infectious agents of laboratory rodents and major impediments to rodent-based research. The original prototypic rodent parvoviruses-minute virus of mice, rat virus, and H-1 virus-have recently been joined by biologically and antigenically distinct parvoviruses in mice, rats, and hamsters. Recognition of the increased diversity of rodent parvoviruses presents new challenges for determining the impact of parvovirus infection on research and for detecting, preventing, and eliminating infection. This review summarizes current knowledge about rodent parvoviruses and parvovirus infections, highlighting recent research on newly isolated virus strains.
Insights
Rodent parvoviruses are common in lab animals, impacting research. New strains increase diversity, posing challenges for detection and prevention.
Area of Science:
- Veterinary Virology
- Laboratory Animal Science
Background:
- Rodent parvoviruses are prevalent infectious agents in laboratory animals.
- These viruses significantly hinder the reliability of rodent-based research.
- Previously known strains include minute virus of mice, rat virus, and H-1 virus.
Purpose of the Study:
- To review current knowledge on rodent parvoviruses.
- To highlight the impact of newly identified parvovirus strains.
- To address challenges in detecting, preventing, and eliminating infections.
Main Methods:
- Literature review of rodent parvovirus research.
- Summary of current knowledge on parvovirus infections.
- Focus on recently isolated and distinct parvovirus strains.
Main Results:
- The diversity of rodent parvoviruses has increased with new isolates.
- These novel strains are biologically and antigenically distinct.
- Increased diversity presents challenges for research integrity and infection control.
Conclusions:
- Understanding the expanded diversity of rodent parvoviruses is crucial.
- New strains necessitate updated strategies for detection and control.
- Effective management of parvovirus infections is vital for research reproducibility.