Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats

S Kobayashi1, M Ohta, K Miyasaka

  • 1Department of Experimental Biology, Tokyo Metropolitan Institute of Gerontology, Japan.

Neuroscience Letters
|August 16, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Vitamin D3 analogue calcipotriol suppresses CpG-activated TLR9-MyD88 signalling in murine plasmacytoid dendritic cells.

Clinical and experimental dermatology·2018
Same author

Updated results from GEST study: a randomized, three-arm phase III study for advanced pancreatic cancer.

Journal of cancer research and clinical oncology·2017
Same author

Randomised phase II trial of S-1 plus oxaliplatin vs S-1 in patients with gemcitabine-refractory pancreatic cancer.

British journal of cancer·2015
Same author

Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan.

British journal of cancer·2010
Same author

Incidence of apoptosis in the pancreas of young and old rats.

Archives of gerontology and geriatrics·2008
Same author

Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population.

Journal of neural transmission (Vienna, Austria : 1996)·2005
Same journal

Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

Neuroscience letters·2026
Same journal

Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

Neuroscience letters·2026
Same journal

Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

Neuroscience letters·2026
Same journal

Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

Neuroscience letters·2026
Same journal

Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

Neuroscience letters·2026
Same journal

Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

Neuroscience letters·2026
See all related articles

Otsuka Long Evans Tokushima Fatty (OLETF) rats, lacking the cholecystokinin-A receptor, exhibit reduced exploratory behavior and movement. This suggests the cholecystokinin-A receptor is crucial for normal activity levels in these rats.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Genetics

Background:

  • Cholecystokinin (CCK) is a prevalent neurotransmitter peptide in the brain.
  • A specific rat strain, Otsuka Long Evans Tokushima Fatty (OLETF) rats, possesses a genetic abnormality leading to a lack of the CCK-A receptor.
  • Understanding the role of CCK-A receptors in behavior is essential.

Purpose of the Study:

  • To investigate potential behavioral abnormalities in OLETF rats lacking the CCK-A receptor.
  • To determine if the absence of CCK-A receptor impacts exploratory behavior.
  • To explore the functional significance of CCK-A receptors in the central nervous system.

Main Methods:

  • Utilized open-field tests to assess behavior in OLETF rats and compare them to normal rats.

Related Experiment Videos

  • Measured CCK release from synaptosomes.
  • Quantified levels of CCK and CCK-B receptor messenger RNAs (mRNAs).

    • Main Results:

    • OLETF rats displayed significantly reduced locomotion (hypolocomotor activity) in open-field tests.
    • A decrease in the incidence of rearing behavior was observed in OLETF rats.
    • CCK release, CCK mRNA, and CCK-B receptor mRNA levels were comparable between OLETF and normal rats.

    Conclusions:

    • The lack of CCK-A receptor in OLETF rats is associated with decreased exploratory behavior and hypolocomotion.
    • The findings suggest a critical role for the CCK-A receptor in regulating motor activity and exploration.
    • The absence of CCK-A receptor, not altered CCK levels or CCK-B receptor expression, appears responsible for the observed behavioral deficits.