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Assignment of Alzheimer's presenilin-1 (PS-1) gene to 14q24.3 by fluorescence in situ hybridization
T Takano1, Y Yamanouchi, N Sahara
1Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Neuroscience Letters
|August 16, 1996
Abstract:
Presenilin-1 (PS-1) was suggested to be localized on 14q24.3 based on linkage analysis and cDNA cloning. The final identification of PS-1 as the causal gene for Alzheimer's disease (AD) was concluded based on finding of the point mutations in the candidate cDNA linked with pedigrees with early-onset familial AD. We present evidence of its physical genome mapping of PS-1 by fluorescence in situ hybridization method.