Related Experiment Video

Updated: Aug 1, 2026

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Clinical, laboratory, and epidemiologic features of a viral gastroenteritis in infants and children

S Tallett, C MacKenzie, P Middleton

    Pediatrics
    |August 1, 1977
    PubMed

    Insights

    Human rotavirus (HRV) causes acute diarrhea in infants, characterized by specific symptoms and stool findings. Early recognition of this infectious illness is crucial for prompt treatment and management.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Virology

    Background:

    • Acute diarrhea in infants is a significant health concern.
    • Human rotavirus (HRV) is a common cause of severe infantile gastroenteritis.

    Purpose of the Study:

    • To describe the clinical presentation and epidemiological features of human rotavirus (HRV) infection in hospitalized infants.
    • To provide data that aids in the diagnosis and management of HRV infections.

    Main Methods:

    • Studied 27 hospitalized infants with acute diarrhea due to HRV.
    • Collected fecal samples and serum antibody titers from patients and household contacts.
    • Analyzed clinical symptoms, dehydration status, and stool characteristics.

    Main Results:

    • HRV infection presented with watery diarrhea, fever, vomiting, dehydration, and metabolic acidosis.
    • Stool analysis showed increased sodium and chloride, with low sugar content.
    • Mild diarrhea recurred in some patients; household contacts showed symptomatic illness and increased HRV antibody titers.

    Conclusions:

    • The clinical pattern of HRV infection is now better defined.
    • Physicians can use this knowledge for quicker recognition and treatment of this infectious disease.
    • Understanding HRV pathogenesis is key to managing this potentially dangerous illness.

    More Related Videos

    Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain05:51

    Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

    Published on: July 24, 2016

    Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions07:59

    Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions

    Published on: September 10, 2021

    Related Concept Videos

    Bacterial Gastroenteritis01:18

    Bacterial Gastroenteritis

    Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
    Viral Meningitis01:18

    Viral Meningitis

    Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
    Poliomyelitis01:17

    Poliomyelitis

    Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
    Viral Hepatitis I: Introduction01:28

    Viral Hepatitis I: Introduction

    Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...