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Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice
1Department of Natural Products, Hebrew University of Jerusalem, Faculty of Medicine, Israel.
Brain Research. Developmental Brain Research
|August 20, 1996
Abstract:
We studied the ontogenetic response to cannabinoid receptor ligands by measuring motor activity and analgesia in response to anandamide or delta 9-THC from day 6 of age. No response to anandamide was observed up to the age of weaning (day 23), while a nonsignificant response to delta 9-THC was observed starting between days 15 and 20. This is compatible with observations that children respond to the antiemetic effects of THC without psychotropic side effects.