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Physical activity, trauma, and ALS: a case-control study

D Strickland¹, S A Smith, G Dolliff

¹Department of Preventive & Societal Medicine, University of Nebraska Medical Center, Omaka 68198-4350, USA.

Acta Neurologica Scandinavica

|July 1, 1996

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Trauma and physical activity may be linked to Amyotrophic Lateral Sclerosis (ALS). Severe injuries and frequent sweating were associated with ALS in a pilot study.

Area of Science:

Neuroscience
Epidemiology

Background:

The relationship between physical activity, trauma, and Amyotrophic Lateral Sclerosis (ALS) remains debated.
Previous research has yielded conflicting results regarding these associations.

Purpose of the Study:

To investigate the potential association between trauma, physical activity, and ALS in a pilot case-control study.
To explore risk factors that may contribute to the development of ALS.

Main Methods:

A case-control study design was employed.
Amyotrophic Lateral Sclerosis (ALS) patients were recruited from a university muscle disease clinic.
Matched controls (clinic-based and community-based) were selected for comparison.

Main Results:

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Significant associations were found between ALS and severe head, neck, and back injuries (OR = 5.3).

Increased frequency of sweating during work (OR = 1.6) and leisure activities (OR = 1.6) showed a strong link to ALS.

Earning a school letter was also significantly associated with ALS (OR = 3.1).

Conclusions:

Trauma and vigorous exercise may precipitate ALS, or trauma could be an early indicator of the disease.
A third, unidentified factor might predispose individuals to both ALS and injury.
Further research with larger sample sizes is recommended to explore less common exposures.