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Updated: Aug 12, 2026

Transthoracic Echocardiography in Mice
Published on: May 28, 2010
Echocardiographic assessment of wall motion in ST-segment alternans during coronary angioplasty
R A Kerensky1, J F Lewis, G J Azar
1Department of Internal Medicine, University of Florida Health Science Center, Gainesville 32610-0277, USA.
Insights
ST alternans, a sign of severe myocardial ischemia, appeared after left ventricular dysfunction. Beat-to-beat contractility variations were not observed, suggesting further research is needed for ischemic heart disease patients.
Area of Science:
- Cardiology
- Electrophysiology
- Myocardial Ischemia Research
Background:
- ST alternans is associated with severe and extensive myocardial ischemia.
- This phenomenon can occur following the onset of ischemia-induced left ventricular dysfunction.
Abstract:
ST alternans occurs in the setting of severe and extensive myocardial ischemia. In this particular case, ST alternans occurred well after the onset of ischemia-induced left ventricular dysfunction. There is no echocardiographic evidence of beat-to-beat variation in contractility to correspond to this ST-segment phenomenon. Further studies of left ventricular function during ST alternans in patients are needed to determine whether this finding applies to all patients with ischemic heart disease.
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