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Quinupristin-dalfopristin

H M Bryson1, C M Spencer

  • 1Adis International Limited, Auckland, New Zealand.

Drugs
|September 1, 1996
PubMed
Summary

Quinupristin-dalfopristin is a potent antibiotic effective against resistant Gram-positive bacteria. Clinical trials show significant improvement in patients with difficult-to-treat infections.

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Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Quinupristin-dalfopristin (RP 59500) is an injectable streptogramin antibiotic.
  • It exhibits broad-spectrum activity against Gram-positive bacteria, including resistant strains like MRSA, VRE, and penicillin-resistant pneumococci.
  • The drug also shows activity against certain anaerobes and Gram-negative pathogens.

Purpose of the Study:

  • To evaluate the efficacy and spectrum of activity of quinupristin-dalfopristin.
  • To assess its effectiveness against bacterial pathogens exhibiting resistance to other antibiotics.
  • To determine its bactericidal activity against key bacterial species.

Main Methods:

  • In vitro susceptibility testing against various bacterial pathogens.
  • Assessment of synergistic activity between quinupristin and dalfopristin.
  • Clinical evaluation in a compassionate use program for patients with vancomycin-resistant Gram-positive infections.

Main Results:

  • Quinupristin-dalfopristin demonstrates potent activity against a wide range of Gram-positive bacteria, including resistant strains.
  • Synergistic action of its components confers resistance to most common bacterial resistance mechanisms.
  • In a compassionate use program, 67% of patients with vancomycin-resistant Gram-positive infections showed clinical improvement.

Conclusions:

  • Quinupristin-dalfopristin is a valuable therapeutic option for infections caused by resistant Gram-positive bacteria.
  • Its unique mechanism of action and broad spectrum make it effective against challenging pathogens.
  • Further clinical studies are warranted to fully establish its role in treating serious infections.

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