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Related Experiment Videos

Altered connexin expression after peripheral nerve injury

K J Chandross1, J A Kessler, R I Cohen

  • 1Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Molecular and Cellular Neurosciences
|June 1, 1996
PubMed
Summary

Peripheral nerve injury alters connexin expression. Connexin46 and connexin43 increase in non-neuronal cells, suggesting a role in nerve repair and regeneration.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Connexin32 (Cx32) is found in myelinating Schwann cells and linked to peripheral neuropathies.
  • Cx32 expression decreases in Schwann cells after nerve crush injury.

Purpose of the Study:

  • To investigate the expression changes of other connexins following peripheral nerve injury.
  • To understand the role of connexin46 (Cx46) and connexin43 (Cx43) in nerve repair.

Main Methods:

  • Analysis of Cx46 and Cx43 mRNA and protein levels in rat sciatic nerve after crush injury.
  • Comparison of protein species and expression patterns in injured versus adult nerve.

Main Results:

  • Cx46 mRNA rapidly increased in degenerating regions by 3 days post-injury, with a shift in protein species.

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  • Cx43 mRNA and protein significantly increased in endoneurial fibroblasts and perineurial cells after injury.
  • Cx43 levels returned to normal by 12 days post-injury.

    • Conclusions:

    • Enhanced expression of Cx46 and Cx43 by non-neuronal cells is crucial for peripheral nerve injury and regeneration.
    • These connexins may play significant roles in the cellular responses to nerve damage.