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Thrombolytic therapy with tissue plasminogen activator for prevention of vasospasm in experimental subarachnoid
1Department of Neurosurgery, Kobe University School of Medicine, Hyougo, Japan.
Neurological Research
|August 1, 1996
Abstract:
We investigated the efficacy of two different tissue plasminogen activators (t-PA) for preventing vasospasm after experimental subarachnoid hemorrhage (SAH) in rabbits. Intrathecal injection of Silteplase and Alteplase showed significant preventive action against vasospasm following SAH and thrombolytic effect. The low dose groups with both t-PA showed more preventive action on day 1 than the high dose groups. The data suggest that the determination of optimum dose of t-PA is essential in clinical use of t-PA.