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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
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Hepatitis B and C viruses in hepatitis B surface antigen negative hepatocellular carcinoma patients

C Bréchot1, M Minami, S De Mitri

  • 1Inserm U370, Paris, France.

Princess Takamatsu Symposia
|January 1, 1995
PubMed

Hepatitis B virus (HBV) has been recognized for a long time as a major etiological factor in hepatocellular carcinoma (HCC) in endemic regions. HCCs occurring in Europe, an area with a low prevalence of HBV infections, are in fact also linked to chronic HBV infection, as revealed by the detection of the viral genome and HBV X gene transcripts in the tumor. There is also a significant association with hepatitis C virus (HCV) infection and a complex interplay may occur between HBV, HCV, and other environmental factors such as alcohol, as well as genetic factors. Preliminary evidence exists for a role of HCV in liver carcinogenesis even without the pre-existing cirrhosis.

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