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Tardive dyskinesia associated with fluoxetine
1Department of Psychiatry, University of Colorado School of Medicine in Denver, USA.
Psychiatric Services (Washington, D.C.)
|September 1, 1996
Summary
Fluoxetine, a common antidepressant, may cause tardive dyskinesia, a movement disorder. This study presents three cases where patients experienced abnormal movements while on fluoxetine.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Pharmacology
Background:
- Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are widely prescribed for depression.
- Tardive dyskinesia (TD) is a neurological disorder characterized by involuntary, repetitive body movements.
- The association between SSRIs and TD is not fully established, with limited case reports.
Observation:
- Three patients on fluoxetine for depression developed movement abnormalities.
- Symptoms included facial, oral, and hand movements suggestive of tardive dyskinesia.
- Onset and duration of symptoms varied, with some persisting after medication withdrawal.
Findings:
- Fluoxetine was associated with the onset or reappearance of tardive dyskinesia in these three cases.
- Movement disorders emerged at different time points, from weeks to years after starting fluoxetine.
- Persistence of symptoms after fluoxetine discontinuation was observed in some patients.
Implications:
- Clinicians should be aware of the potential risk of fluoxetine-induced tardive dyskinesia.
- Further research is needed to understand the mechanism and prevalence of TD associated with fluoxetine.
- Monitoring for movement disorders is crucial in patients treated with fluoxetine, especially long-term.