Novel scaffolds for non-peptide mimetics of delta opioid receptor agonists based on peptide leads

The interaction of a benzodiazepine receptor antagonist (Ro15-1788) with GABA and GABA receptor antagonists at the GABA(A) receptor chloride-ionophore complex.

Neurochemistry international·2010

Functional selectivity in cannabinoid signaling.

Current molecular pharmacology·2009

Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.

European journal of pharmacology·2001

Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.

Molecular pharmacology·2001

Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen2, D-Pen5]-enkephalin (DPDPE).

The Journal of pharmacology and experimental therapeutics·2001

Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation.

Life sciences·2001

WITHDRAWN: Effects of centrally-injected glucagon-like peptide-2 on gastric mucosal blood flow in rats; possible mechanisms.

Regulatory peptides·2014

Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene.

Regulatory peptides·2014

Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue.

Regulatory peptides·2014

Insulin-like growth factor-1 inhibits colonic smooth muscle cell apoptosis in diabetic rats with colonic dysmotility.

Regulatory peptides·2014

Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats.

Regulatory peptides·2014

Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors.

Regulatory peptides·2014

A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization.

ArXiv·2026

Reimagining productive chemical space for RNA recognition beyond aromaticity.

bioRxiv : the preprint server for biology·2026

Sulfathiazole scaffold remodeling into benzothiazole-thiazole Schiff bases: Antibacterial activity against Staphylococcus aureus, structure-activity relationships, and integrated DFT, docking and molecular dynamics studies.

Bioorganic chemistry·2026

New carbazole-5-phenoxymethyl-1,2,4-triazole derivatives as multi-target inhibitors towards α-glucosidase, α-amylase and PTP1B: Construction, biological evaluation, and mechanism investigation.

European journal of medicinal chemistry·2026

Masked Bisphosphonate Inhibitors of Acid Sphingomyelinase: Improved Cell Penetration and Potency.

ACS chemical biology·2026

CIM-DTA: Conditional Interaction Modulation for Cold-Start Drug-Target Affinity Prediction.

IEEE transactions on computational biology and bioinformatics·2026

Related Experiment Videos

Novel scaffolds for non-peptide mimetics of delta opioid receptor agonists based on peptide leads

Related Concept Videos

The interaction of a benzodiazepine receptor antagonist (Ro15-1788) with GABA and GABA receptor antagonists at the GABA(A) receptor chloride-ionophore complex.

Functional selectivity in cannabinoid signaling.

Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.

Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.

Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen2, D-Pen5]-enkephalin (DPDPE).

Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation.

WITHDRAWN: Effects of centrally-injected glucagon-like peptide-2 on gastric mucosal blood flow in rats; possible mechanisms.

Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene.

Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue.

Insulin-like growth factor-1 inhibits colonic smooth muscle cell apoptosis in diabetic rats with colonic dysmotility.

Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats.

Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors.

A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization.

Reimagining productive chemical space for RNA recognition beyond aromaticity.

Sulfathiazole scaffold remodeling into benzothiazole-thiazole Schiff bases: Antibacterial activity against Staphylococcus aureus, structure-activity relationships, and integrated DFT, docking and molecular dynamics studies.

New carbazole-5-phenoxymethyl-1,2,4-triazole derivatives as multi-target inhibitors towards α-glucosidase, α-amylase and PTP1B: Construction, biological evaluation, and mechanism investigation.

Masked Bisphosphonate Inhibitors of Acid Sphingomyelinase: Improved Cell Penetration and Potency.

CIM-DTA: Conditional Interaction Modulation for Cold-Start Drug-Target Affinity Prediction.

Related Experiment Videos

Novel scaffolds for non-peptide mimetics of delta opioid receptor agonists based on peptide leads

Related Concept Videos

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