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Papular-purpuric gloves-and-socks syndrome
E Vargas-Díez1, G F Buezo, M Aragües
1Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain.
International Journal of Dermatology
|September 1, 1996
Summary
Papular-purpuric gloves-and-socks syndrome (PPGSS) is a distinct dermatosis often caused by human parvovirus B19 (HPV B19). This study confirms HPV B19
Area of Science:
- Dermatology
- Virology
- Immunology
Background:
- Papular-purpuric gloves-and-socks syndrome (PPGSS) is a recently identified skin condition.
- Human parvovirus B19 (HPV B19) is a suspected but not sole causative agent.
- The study aimed to characterize PPGSS and investigate the role of HPV B19.
Observation:
- PPGSS presents with a consistent clinical presentation.
- Histological and immunofluorescence findings are generally non-specific.
- Serum analysis revealed HPV B19 seroconversion in some cases.
Findings:
- HPV B19 infection was confirmed in two patients.
- A potential role for Coxsackie virus B6 was suggested in one instance.
- The study identified PPGSS as a manifestation of HPV B19 infection.
Implications:
- PPGSS is a distinct dermatosis linked to HPV B19.
- Antibody development in PPGSS cases appears delayed compared to erythema infectiosum.
- Viremia may persist longer in PPGSS patients with anti-HPV B19 antibodies.