Related Experiment Video
Updated: Oct 9, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Lower respiratory tract infections among Norwegian infants with siblings in day care
Insights
Infants with siblings, especially those attending daycare, face a higher risk of lower respiratory tract infections. This highlights the importance of considering sibling contact when assessing infant infection risk.
Area of Science:
- Pediatrics
- Epidemiology
- Infectious Diseases
Background:
- Lower respiratory tract infections (LRTIs) are a significant cause of infant morbidity.
- The role of household contacts, particularly siblings, in disease transmission is increasingly recognized.
Purpose of the Study:
- To investigate the association between siblings, specifically those attending day care, and the risk of LRTIs in infants.
- To quantify the impact of sibling presence and day care attendance on infant respiratory health.
Main Methods:
- A prospective cohort study involving 3238 newborns in Oslo, Norway, recruited in 1992/93.
- Infants were followed for one year to ascertain the incidence of LRTIs.
- Logistic regression analysis was used to assess risk factors.
Main Results:
- Infants with one or more siblings had a significantly increased risk of infection (adjusted odds ratio [OR] = 2.3).
- Infants with siblings attending day care showed a further increased risk compared to those with siblings not in day care (adjusted OR = 1.7).
Conclusions:
- The presence of siblings is a determinant of infants' risk for lower respiratory tract infections.
- Siblings attending day care outside the home represent a specific risk factor, increasing infant susceptibility to LRTIs.
Objectives:
The purpose of this study was to assess the role of siblings in day care as a determinant of infants' risk of lower respiratory tract infections.
Methods:
A total of 3238 children (86%) out of 3754 Oslo, Norway, newborns recruited in 1992/93 were followed for 1 year.
Results:
In logistic regression analysis, the risk of infection was increased in (1) infants with one or more siblings compared with infants without siblings (adjusted odds ratio [OR] = 2.3; 95% confidence interval [CI] = 1.84, 2.85) and (2) infants with one or more siblings in day care compared with infants with siblings not in day care (adjusted OR = 1.7; 95% CI = 1.21, 2.26).
Conclusions:
The results suggest that siblings in day care outside the home increase infants' risk of lower respiratory tract infections.
Related Concept Videos
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Development of the Oral Microbiota
Microbiota of the Respiratory Tract
Respiratory Syncytial Virus Disease
Pneumonia I: Introduction
Sibling Relationships During Infancy and Toddlerhood

