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Decrease in selenium status in relation to coal dust exposure
M P Oryszczyn1, J Godin, C Frette
1INSERM Unit 169, Villejuif, France.
American Journal of Industrial Medicine
|September 1, 1996
Summary
Selenium (Se) plasma levels were found to be lower in coal miners with higher coal dust exposure. This association persisted even after accounting for age and tobacco use, indicating a potential health risk.
Area of Science:
- Occupational Health
- Environmental Toxicology
- Biochemistry
Background:
- Coal mining involves significant exposure to airborne particulates.
- Selenium is an essential trace element with antioxidant properties.
- Factors like age and lifestyle can influence selenium levels.
Purpose of the Study:
- To investigate the relationship between coal dust exposure and plasma selenium levels in coal miners.
- To determine if age, alcohol, or tobacco consumption modify this relationship.
Main Methods:
- Plasma selenium levels were measured in 222 coal miners.
- Exposure to coal dust was categorized (long-term, current, never/slight).
- Statistical analysis adjusted for age, alcohol, and tobacco consumption.
Main Results:
- Selenium levels significantly decreased with age and current tobacco consumption in miners aged 34-50.
- Miners with both long-term and current coal dust exposure had the lowest selenium levels (60.2 ng/ml).
- The association between coal dust exposure and lower selenium remained significant after adjustments.
Conclusions:
- Occupational exposure to coal dust is associated with reduced plasma selenium levels in miners.
- Age and smoking are also significant factors influencing selenium levels.
- Further research into selenium supplementation or protective measures for miners may be warranted.