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Related Experiment Videos

Placebo response in anxiety disorders

M A Piercy1, J J Sramek, N M Kurtz

  • 1California Clinical Trials, Beverly Hills 90211, USA.

The Annals of Pharmacotherapy
|September 1, 1996
PubMed
Summary

Anxiety disorder clinical trials show varied placebo response rates, often high in generalized anxiety and panic disorders but low in social phobia and OCD. Careful study design is crucial to prevent high placebo effects masking true drug efficacy.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Anxiety disorders are highly susceptible to patient and environmental factors.
  • Placebo response rates in clinical trials for anxiety medications vary significantly.
  • High placebo response can obscure the true efficacy of anxiolytic drugs.

Purpose of the Study:

  • To review existing literature on placebo response in anxiety disorders.
  • To identify sources and levels of placebo response across different anxiety conditions.
  • To propose methods for mitigating high placebo response rates in clinical research.

Main Methods:

  • Literature search of scientific articles using MEDLINE.
  • Extraction and summarization of data from diverse study types.
  • Inclusion of English-language human studies and representative review conclusions.

Main Results:

  • Generalized anxiety disorder and panic disorder studies report high placebo response rates.
  • Social phobia and obsessive-compulsive disorder studies show consistently low placebo response.
  • Placebo response rates in anxiety mirror those found in depression studies.

Conclusions:

  • Placebo response in anxiolytic trials is influenced by endogenous and exogenous factors.
  • Poor study design and lack of standardization can lead to inflated placebo rates.
  • Implementing specific design strategies can help reduce high placebo response in anxiety trials.

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