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Lymphocyte subset diversity in idiopathic CD4+ T lymphocytopenia
P Tassinari1, L Deibis, N Bianco
1Instituto de Immunología, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.
Clinical and Diagnostic Laboratory Immunology
|September 1, 1996
Abstract:
The clinical and public health importance of CD4+ T lymphocytopenia without human immunodeficiency virus infection is still unclear. We describe herein two new human immunodeficiency virus-negative patients with low numbers of peripheral CD4+ T cells and opportunistic infections (cerebral toxoplasmosis and tuberculosis plus extrapulmonary histoplasmosis). The low numbers of CD4+ CD29+ memory cells, the high percentage of gamma delta T-cell receptor cells, and the recovery of CD4+ cells after treatment were remarkable.