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The use of omeprazole for resistant oesophagitis in children
P B Martin1, S M Imong, J Krischer
1Institute of Child Health, St. Michael's Hill, Bristol, UK.
Insights
Omeprazole effectively treated reflux oesophagitis in children when standard therapies failed. Most children experienced symptom relief, with few side effects reported during this study.
Area of Science:
- Pediatric Gastroenterology
- Pharmacology
Background:
- Reflux oesophagitis is a common condition in children.
- Conventional therapies can fail in some pediatric cases.
Purpose of the Study:
- To evaluate the efficacy and safety of omeprazole in children with reflux oesophagitis refractory to conventional treatment.
Main Methods:
- A cohort of 15 children with reflux oesophagitis received omeprazole (20 mg daily) for up to three months.
- Symptomatic outcomes including pain, vomiting, dysphagia, and haematemesis were assessed.
Main Results:
- Marked symptomatic improvement was observed in the majority of treated children.
- Four children (26.7%) did not respond to omeprazole and required fundoplication.
- No complications were reported during omeprazole treatment.
Conclusions:
- Omeprazole is a safe and effective treatment option for pediatric reflux oesophagitis unresponsive to conventional therapy.
- Long-term treatment with omeprazole is feasible for some children.
Abstract:
Following failure of conventional therapy for reflux oesophagitis, 15 children were treated with omeprazole 20 mg daily for a period of up to three months initially. Treatment resulted in a marked symptomatic improvement as measured by incidence of pain, vomiting, dysphagia and haematemesis. Four children failed treatment and required fundoplication. No complications from the use of omeprazole were recorded and some children have continued long-term treatment.