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Updated: Sep 10, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Primary structure of bovine adenosine deaminase
M A Kelly1, M M Vestling, C M Murphy
1Department of Chemistry and Biochemistry, University of Maryland Baltimore County 21228, USA.
Abstract:
Derivatized bovine adenosine deaminase is used in enzyme replacement therapy and as an adjunct to gene therapy against severe combined immunodeficiency syndrome. Although a gene sequence is known for human adenosine deaminase, the structure of the bovine enzyme has not been characterized. Structure studies using mass spectrometry are reported here that evaluate sequence, processing, post-translational modifications and the extent of homology between the human protein and its therapeutic surrogate.
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