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Sustained-release subconjunctival 5-fluorouracil
Ophthalmic Surgery and Lasers
|September 1, 1996
Abstract
Background And Objectives:
The purpose of this research was to obtain preliminary safety and efficacy data on a novel sustained-release 5-fluorouracil (5-FU) implant in high-risk glaucoma surgical patients.
Patients And Methods:
The implants were placed subconjunctivally in four patients undergoing high-risk trabeculectomy. The patients have been observed for approximately 2.5 years.
Results:
In three of the four patients intraocular pressure was controlled at less than 21 mm Hg, with stabilization of the visual field. One patient had early failure. No untoward events were linked to the placement of the implant.
Conclusion:
Sustained-release systems for subconjunctival 5-FU may be useful in filter maintenance.