Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

928
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
928
Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

1.5K
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
1.5K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

4.8K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
4.8K
Direct-Acting Cholinergic Agonists: Pharmacokinetics01:31

Direct-Acting Cholinergic Agonists: Pharmacokinetics

1.8K
Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression.

Nature communications·2024
Same author

[Vascular age and cardiovascular risk in hypertensive patients followed at the heart institute].

Annales de cardiologie et d'angeiologie·2023
Same author

Informing Precision Home Visiting: Identifying Meaningful Subgroups of Families Who Benefit Most from Family Spirit.

Prevention science : the official journal of the Society for Prevention Research·2019
Same author

Effect of laser suture lysis on filtration openings: a prospective three-dimensional anterior segment optical coherence tomography study.

Eye (London, England)·2015
Same author

Comparison of visual field progression between temporally tilted disc and nontilted disc, in patients with normal tension glaucoma.

Eye (London, England)·2015
Same author

Longitudinal analysis of age-related changes in intraocular pressure in South Korea.

Eye (London, England)·2015

Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
05:19

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery

Published on: December 1, 2023

1.6K

Aceclidine effects on outflow facility after ciliary muscle disinsertion

W C Hubbard1, C Kee, P L Kaufman

  • 1Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53792-3220, USA.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|January 1, 1996
PubMed
Summary

Aceclidine

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.8K
A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

10.9K

Related Experiment Videos

Last Updated: Jan 8, 2026

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
05:19

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery

Published on: December 1, 2023

1.6K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.8K
A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

10.9K

Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Aceclidine is known to improve aqueous humor outflow facility with minimal accommodative impact.
  • The precise mechanism, whether involving the ciliary muscle (CM) or trabecular meshwork (TM), remains unclear.

Purpose of the Study:

  • To investigate whether aceclidine's dissociation of outflow facility and accommodation is mediated by the ciliary muscle (CM) or trabecular meshwork (TM).

Main Methods:

  • Rhesus monkey model with unilateral ciliary muscle (CM) disinsertion from the trabecular meshwork (TM).
  • Measurement of perfusion outflow facility and accommodative response following administration of pilocarpine, cytochalasin B, carbachol, and aceclidine HCl.
  • Comparison of drug effects between control and CM-disinserted eyes.

Main Results:

  • Pilocarpine response was significantly reduced in CM-disinserted eyes compared to controls.
  • Cytochalasin B, a TM-acting agent, induced a facility increase in CM-disinserted eyes, unlike in control eyes.
  • Aceclidine HCl increased outflow facility in control eyes in a dose-dependent manner, but responses were markedly attenuated in CM-disinserted eyes.

Conclusions:

  • Aceclidine's effect on outflow facility appears to be primarily mediated through the ciliary muscle (CM).
  • A higher dose of aceclidine may exert a secondary effect on the trabecular meshwork (TM) or act on remaining CM-TM attachments.
  • The dissociation of accommodative effect and outflow facility improvement by aceclidine is likely due to its action on the CM.