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Related Experiment Videos

Pentagastrin has panic-inducing properties in obsessive compulsive disorder

A S de Leeuw1, J A Den Boer, B R Slaap

  • 1Department of Psychiatry, Academic Hospital Utrecht, The Netherlands.

Psychopharmacology
|August 1, 1996
PubMed
Summary

Pentagastrin, a CCK-4 analogue, induced panic-like reactions in most patients with obsessive compulsive disorder (OCD). This suggests a potential shared neurobiological link between OCD and panic disorder involving CCK-B receptors.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Obsessive compulsive disorder (OCD) is a debilitating mental health condition.
  • Cholecystokinin (CCK) peptides and their receptors are implicated in anxiety and related disorders.
  • CCK-B receptor agonists, like pentagastrin, have been investigated for their effects on anxiety.

Purpose of the Study:

  • To investigate the effects of pentagastrin, a CCK-B receptor agonist, on patients with OCD.
  • To compare the response to pentagastrin in OCD patients versus healthy controls.
  • To assess whether pentagastrin influences core OCD symptoms.

Main Methods:

  • A double-blind, placebo-controlled study involving seven OCD patients and seven healthy controls.
  • Intravenous administration of pentagastrin (0.6 micrograms/kg) or placebo on separate occasions.

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  • Assessment of panic-like reactions and OCD symptoms using standardized scales.

    • Main Results:

    • A significantly higher incidence of panic-like reactions was observed in OCD patients (86%) compared to controls (29%) after pentagastrin administration.
    • These differences did not reach statistical significance, likely due to the small sample size.
    • Pentagastrin did not increase obsessions or compulsive behaviors in either group.

    Conclusions:

    • Pentagastrin exhibits panic-inducing properties in individuals with OCD, independent of core OCD symptoms.
    • The panic-inducing effects of pentagastrin are not exclusive to panic disorder patients.
    • These findings suggest a potential common neurobiological dysfunction involving CCK-B receptors in both panic disorder and OCD.