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Elevated endothelin-1 levels and persistent stage IV hypertension in a nonvolume overloaded anephric patient
Z Vajo1, R A Moffitt, S Parvathala
1Department of Medicine, Maricopa Medical Center, Phoenix, Arizona 85008, USA.
American Journal of Hypertension
|September 1, 1996
Abstract:
Persistent hypertension after nephrectomy is in most cases due to increased fluid volume. Endothelin-1 is a potent endogenous vasoconstrictor peptide. Its role in the development and maintenance of hypertension is not completely understood, but it might be significant in some cases. We report a case of stage IV hypertension after nephrectomy with elevated endothelin-1 levels and no volume overload.