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Related Experiment Videos

Ondansetron alters human alcohol intoxication

R M Swift1, D Davidson, W Whelihan

  • 1Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, Rhode Island, USA.

Biological Psychiatry
|September 15, 1996
PubMed
Summary

The serotonin-3 (5-HT3) antagonist ondansetron increased subjective alcohol intoxication effects in social drinkers. This may explain how ondansetron reduces alcohol consumption by enhancing intoxication and aversive responses.

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Area of Science:

  • Neuropharmacology
  • Behavioral Science

Background:

  • Serotonin-3 (5-HT3) receptor antagonists are known to influence alcohol's behavioral effects and potentially reduce alcohol consumption.
  • The precise mechanisms by which 5-HT3 antagonists affect alcohol-related behaviors require further elucidation.

Purpose of the Study:

  • To investigate the effects of the 5-HT3 antagonist ondansetron on subjective and objective measures of alcohol intoxication in social drinkers.
  • To clarify the mechanism of action of 5-HT3 antagonists in modulating alcohol's effects.

Main Methods:

  • A crossover, double-blind protocol was employed with 12 nonalcoholic social drinkers receiving either 8 mg ondansetron or placebo, followed by an intoxicating alcohol dose.
  • Subjective and objective intoxication measures, including mood, physical sensations, and performance, were assessed.

Related Experiment Videos

  • A separate protocol with 10 subjects examined ondansetron's effects with a placebo alcohol dose to control for its direct effects.

    • Main Results:

    • Ondansetron augmented specific stimulant, sedative, and discriminant effects of alcohol.
    • No significant impact was observed on psychomotor performance or alcohol pharmacokinetics.
    • Ondansetron demonstrated minimal effects when subjects received a placebo alcohol dose.

    Conclusions:

    • The observed reductions in alcohol consumption with ondansetron may be linked to heightened subjective intoxication.
    • Increased aversive effects of alcohol, potentially mediated by ondansetron, could also contribute to reduced consumption.
    • These findings provide insight into the neurobiological pathways influenced by 5-HT3 antagonism in the context of alcohol use.