Related Experiment Video

Updated: Aug 14, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 18, 2010

Syphilitic meningitis with papilledema

G M Trenholme, A A Harris, P P McKellar

    Southern Medical Journal
    |August 1, 1977
    PubMed

    Insights

    Syphilitic meningitis can mimic brain tumors, causing papilledema. Early penicillin treatment is crucial for patients with syphilitic meningitis to prevent severe neurological damage.

    Area of Science:

    • Neuroscience
    • Infectious Diseases
    • Ophthalmology

    Background:

    • Syphilitic meningitis is a serious neurological complication of syphilis.
    • Intracranial mass lesions can present with papilledema.
    • The etiology of papilledema in neurosyphilis can be complex.

    Observation:

    • A patient presented with papilledema and symptoms suggestive of an intracranial mass lesion.
    • The papilledema in this case was not clearly attributable to elevated intracranial pressure.

    Findings:

    • The patient was diagnosed with syphilitic meningitis.
    • The clinical presentation initially mimicked an intracranial mass.

    Implications:

    • Prompt diagnosis and treatment of syphilitic meningitis with penicillin are essential.
    • Timely intervention can prevent irreversible neurological sequelae.
    • This case highlights the importance of considering neurosyphilis in the differential diagnosis of papilledema.

    More Related Videos

    Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells09:35

    Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

    Published on: May 19, 2020

    Integrated Protocol for Assessing Meningeal Lymphatics: Cisterna Magna Injection, Lymph Node Imaging, Meningeal Dissection, and Whole-Mount Staining07:59

    Integrated Protocol for Assessing Meningeal Lymphatics: Cisterna Magna Injection, Lymph Node Imaging, Meningeal Dissection, and Whole-Mount Staining

    Published on: May 29, 2026

    Related Concept Videos

    Bacterial Meningitis01:24

    Bacterial Meningitis

    Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
    Viral Meningitis01:18

    Viral Meningitis

    Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
    Cryptococcal Meningitis01:27

    Cryptococcal Meningitis

    Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
    Bacterial Meningitis I: Introduction01:22

    Bacterial Meningitis I: Introduction

    Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
    Bacterial Meningitis II: Pathophysiology01:26

    Bacterial Meningitis II: Pathophysiology

    Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
    Brain Abscess l: Introduction01:26

    Brain Abscess l: Introduction

    A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...