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Sensorineural deafness in siblings with adenosine deaminase deficiency
1Division of Child Neurology, Institute of Neurological Sciences, Tottori University, School of Medicine, Japan.
Brain & Development
|July 1, 1996
Summary
Adenosine deaminase deficiency treatment with bone marrow transplant led to immune recovery but also sensorineural deafness. This suggests deafness may be a neurological complication of adenosine deaminase deficiency.
Area of Science:
- Immunology
- Genetics
- Neurology
Background:
- Adenosine deaminase (ADA) deficiency is a severe combined immunodeficiency.
- Allogeneic bone marrow transplantation (BMT) is a potential treatment for ADA deficiency.