Lack of effect of the serotonin4 receptor agonist zacopride on ACTH secretion in normal men
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H Lefebvre1, V Contesse, C Delarue
1Clinique Médicale et Endocrinologique, Hôpital de Boisguillaume, CHU de Rouen, France.
Objective:
In the present study, we investigated the effect of zacopride on corticotropin (ACTH) and cortisol secretion in healthy volunteers. Male subjects received a single oral dose of placebo, 10 micrograms zaco-pride or 400 micrograms zacopride. Plasma ACTH, cortisol and aldosterone concentrations were measured before and during the 3 h following the administration of the drug.
Results:
For none of the doses did zacopride cause any modification of plasma ACTH or cortisol levels. In contrast, administration of 400 micrograms zacopride induced a significant increase in plasma aldosterone levels.
Conclusion:
Our results indicate that in humans serotonin-evoked stimulation of ACTH secretion is not mediated through serotonin4 (5-HT4) receptors. Together with previous findings, these data indicate that the stimulatory effect of 5-HT4 receptor agonists on aldosterone secretion in man can be ascribed solely to a direct action on glomerulosa cells.