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Pharmacokinetics of lysine clonixinate in children in postoperative care
G González-Martin1, C Cattan, S Zuñiga
1Department of Pharmacy, Faculty of Chemistry, Pontifical Catholic University of Chile, Santiago, Chile.
Insights
This study examined lysine clonixinate pharmacokinetics in children, finding no significant differences in drug clearance or half-life between doses. Pediatric pharmacokinetic parameters differ from adult values.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Clinical Pharmacy
Background:
- Lysine clonixinate is an analgesic used in postoperative care.
- Understanding its pharmacokinetics in children is crucial for safe and effective dosing.
Purpose of the Study:
- To evaluate the pharmacokinetics of two intravenous doses of lysine clonixinate (4 and 6 mg/kg) in children.
- To compare pharmacokinetic parameters between the two doses and with existing adult data.
Main Methods:
- A single intravenous dose of lysine clonixinate was administered to 10 children (aged 4-10 years).
- Serum clonixin concentrations were measured over 3 hours using high-performance liquid chromatography.
- Pharmacokinetic parameters were calculated using a nonlinear computer program.
Main Results:
- Volume of distribution was similar between the 4 mg/kg and 6 mg/kg groups.
- Total plasma clearance and elimination half-life showed no statistically significant differences between the two doses.
- Elimination half-life was slightly longer in the 6 mg/kg group (44.26 min) compared to the 4 mg/kg group (38.63 min).
Conclusions:
- Intravenous lysine clonixinate exhibits similar pharmacokinetic profiles at 4 and 6 mg/kg doses in children.
- Pediatric pharmacokinetic parameters for lysine clonixinate appear to differ from those reported in adults and experimental animals.
Abstract:
The pharmacokinetics of 2 doses of intravenous lysine clonixinate (4 and 6 mg x kg-1) were studied in 10 children (age 4-10 years) under postoperative care. A single dose of the drug was injected in a forearm vein. Blood samples were collected at regular intervals for 3 hours. Serum clonixin concentrations (expressed as clonixin) were analyzed using a high pressure liquid chromatography method. Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume was similar in both groups of children (1.288 +/- 0.829 1 and 1. 139 +/- 0.667 1, respectively). There were no differences between the values of total plasma clearance and the administered doses (0.026 +/- 0.017 ml x min-1 and 0.017 +/- 0.008 ml x min-1, t = 1.07, p = 0.76). The elimination half-life was longer in children who received 6 mg x kg-1 (44.26 +/- 6.34 min vs 38.63 +/- 10.93 min) but this difference was not statistically significant (t = 0.99, p < 0.34). The pharmacokinetic parameters calculated in these children were different from those found by other authors in adults and experimental animals.