Related Experiment Videos
MHCDB: database of the human MHC (release 2)
W R Newell1, J Trowsdale, S Beck
1Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Immunogenetics
|January 1, 1996
Summary
The updated human Major Histocompatibility Complex (MHC) database is now available, featuring enhanced genomic data and disease associations. This resource aids research into immune system genetics and disease links.
Area of Science:
- Immunogenetics
- Genomics
- Bioinformatics
Background:
- The human Major Histocompatibility Complex (MHC) is crucial for immune response and disease susceptibility.
- Previous versions of the MHC database provided foundational genetic information.
Purpose of the Study:
- To release an updated and expanded version of the human MHC database.
- To provide researchers with comprehensive genomic and functional data for MHC genes.
Main Methods:
- Database compilation and integration of updated physical maps and genomic sequences.
- Inclusion of cDNA sequences for all known alleles.
- Graphical representation of gene variability using static and dynamic images.
- Integration of disease-serotype associations and eluted peptide data from MHCPEP.
Main Results:
- The second release of the human MHC database is publicly accessible.
- The database includes an updated physical map and significantly increased genomic sequence data.
- Individual sequence entries are available for all current cDNA alleles.
- Graphical displays illustrate the variability of different MHC genes.
- Incorporation of known disease-serotype associations and MHCPEP data.
Conclusions:
- The enhanced human MHC database serves as a valuable, comprehensive resource for immunogenetics and related research.
- Improved accessibility to detailed genomic and disease-association data facilitates studies on immune function and pathology.