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[Acromegaly]

I Morange1, P Jaquet

  • 1Service d'endocrinologie, Centre hospitalo-universitaire de la Timone, Marseille.

La Revue Du Praticien
|June 15, 1996
PubMed
Summary
This summary is machine-generated.

Acromegaly, often caused by pituitary tumors, is diagnosed late due to its slow progression. Early detection of high insulin growth factor 1 and growth hormone is key for effective treatment.

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Area of Science:

  • Endocrinology
  • Oncology

Context:

  • Acromegaly is a chronic endocrine disorder characterized by excessive growth hormone production, typically from a pituitary adenoma.
  • The condition's insidious onset often results in delayed diagnosis, frequently when significant complications arise.
  • Diagnostic challenges include the subtle presentation and the need for specific biochemical testing.

Purpose:

  • To outline the diagnostic criteria for acromegaly.
  • To describe the primary and alternative treatment modalities for this condition.
  • To emphasize the importance of early detection and management.

Summary:

  • Acromegaly diagnosis, predominantly linked to pituitary adenomas (>95%), is primarily a clinical syndrome with slow progression, often leading to diagnosis at the complication stage (cardio-respiratory, diabetes).

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  • Biological diagnosis involves elevated insulin growth factor 1 (IGF1) and growth hormone (GH) levels, unresponsive to oral glucose suppression.
  • Initial treatment is surgical (transsphenoidal selective adenomectomy), with radiation and medical therapies (dopaminergic or somatostatinergic drugs) reserved for surgical failures.

    • Impact:

    • Highlights the clinical and biochemical hallmarks of acromegaly for timely diagnosis.
    • Provides an overview of current therapeutic strategies, guiding clinical decision-making.
    • Underscores the impact of delayed diagnosis on patient outcomes and the need for effective management.