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Multiple myeloma involving the thyroid cartilage

C W Van Dyke1, T J Masaryk, P Lavertu

  • 1Department of Radiology, Cleveland (Ohio) Clinic Foundation 44195, USA.

AJNR. American Journal of Neuroradiology
|March 1, 1996
PubMed
Summary

Extraosseous multiple myeloma rarely affects the larynx. This case report suggests ossification of the thyroid cartilage may create a marrow space, enabling myeloma development in this uncommon site.

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Area of Science:

  • Oncology
  • Pathology
  • Anatomy

Background:

  • Multiple myeloma is a plasma cell malignancy typically affecting bone marrow.
  • Extraosseous involvement, while known, is infrequent, with laryngeal presentation being exceptionally rare.

Observation:

  • A case of multiple myeloma with a plasmacytoma localized to the thyroid cartilage is presented.
  • The tumor involved the laryngeal structure, specifically the thyroid cartilage.

Findings:

  • The study hypothesizes that ossification of the thyroid cartilage, leading to the formation of a marrow space, could be the underlying mechanism for this unusual myeloma localization.
  • This provides a potential explanation for the occurrence of myeloma in this extraosseous site.

Implications:

  • Understanding the potential for marrow space formation in laryngeal cartilage is crucial for diagnosing and managing rare myeloma presentations.
  • This finding may prompt further investigation into the anatomical and pathological factors contributing to extraosseous myeloma.
  • Highlights the importance of considering unusual sites for myeloma recurrence or metastasis.

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