[Selective transfection of animal cells by non viral vectors: polylysine carrying recognition signals]
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M Monsigny1, P Midoux, A C Roche
1Glycobiologie, Centre de Biophysique moléculaire, CNRS et Université d'Orléans, France.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1996
Abstract:
A process for the selective transfer of genes using glycosylated polylysine was established. Glycosylated polylysines and plasmid DNA form complexes which are taken up by cells expressing surface lectins recognizing the sugar moieties of glycosylated polylysines. Modifications made to this process allow for efficient and specific transfer in in vitro animal cell models.