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[Digestive manifestations in hemolytic uremic syndrome in children]

A Bernard1, P Tounian, B Leroy

  • 1Service de gastroentérologie et nutrition pédiatriques, hôpital Armand-Trousseau, Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|June 1, 1996
PubMed

Insights

Gastrointestinal issues are common in hemolytic uremic syndrome (HUS), with severe cases impacting kidney outcomes. Early recognition of severe gut involvement is crucial for patient prognosis and management.

Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Hematology

Context:

  • Hemolytic uremic syndrome (HUS) frequently presents with gastrointestinal (GI) symptoms.
  • These GI manifestations can necessitate specialized supportive care.
  • Understanding the prognostic significance of GI involvement in HUS is critical.

Purpose:

  • To retrospectively study the spectrum of GI manifestations in pediatric HUS.
  • To identify clinical indicators associated with severe GI involvement.
  • To determine the relationship between GI lesions and HUS prognosis.

Summary:

  • Thirty-seven children with HUS were analyzed for GI complications.
  • Bloody diarrhea, intussusception, rectal prolapse, and hepatic cytolysis were observed.
  • Indicators of severe gut involvement included female sex, short prodromal duration, hemorrhagic colitis with rectal prolapse, and specific blood counts.

Impact:

  • GI tract involvement is common in HUS and can lead to severe, potentially fatal complications.
  • Severe GI lesions correlate with poorer renal outcomes in HUS patients.
  • Total parenteral nutrition may help prevent GI complications in HUS.
Abstract

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