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Published on: April 7, 2015
[Neurologic manifestations of Mycoplasma pneumoniae infections]
M C Delmas1, C Gauthier, F Rapin
1Service de pédiatrie, centre hospitalier, Gap, France.
Background:
Some neurological manifestations associated with Mycoplasma pneumoniae infection have been reported, such as meningoencephalitis, cerebellitis, aseptic meningitis, polyradiculopathy, transverse myelitis, cranial nerve palsies and myositis.
Case Report:
Case 1. A 10 year-old boy had an acute pneumonia that was subsequently proven to be due to Mycoplasma pneumoniae infection. This infection was resistant to macrolid administration for 1 week requiring the administration of vibramycin instead. At that time, the patient developed an aseptic meningitis syndrome and a severe cerebellitis. He completely recovered within a few days. Case 2. A boy was admitted because he suffered from polyradiculopathy that had appeared during an acute episode of pneumonia. The neurological involvement extended to cranial nerves, then subsequently completely disappeared. Seroimmunological studies confirmed the Myoplasma pneumoniae infection.
Conclusion:
The mechanism of these classical but rare neurological manifestations remains unclear.
Insights
Mycoplasma pneumoniae can cause rare neurological issues like meningitis and cerebellitis in children. Prompt treatment led to full recovery in reported cases, though underlying mechanisms require further study.
Area of Science:
- Neurology
- Infectious Diseases
- Pediatrics
Background:
- Mycoplasma pneumoniae infections are linked to various neurological complications.
- Reported neurological manifestations include meningoencephalitis, cerebellitis, aseptic meningitis, polyradiculopathy, transverse myelitis, cranial nerve palsies, and myositis.
Observation:
- Case 1: A 10-year-old boy with Mycoplasma pneumoniae pneumonia developed aseptic meningitis and cerebellitis, resistant to macrolides but treated successfully with vibramycin.
- Case 2: A boy presented with polyradiculopathy during Mycoplasma pneumoniae pneumonia, with subsequent cranial nerve involvement, followed by complete neurological recovery.
Findings:
- Two pediatric cases illustrate Mycoplasma pneumoniae-associated neurological syndromes.
- Successful treatment outcomes were observed with appropriate antimicrobial therapy and supportive care.
Implications:
- These cases highlight the spectrum of neurological involvement in Mycoplasma pneumoniae infections.
- The underlying mechanisms of these rare neurological manifestations remain to be elucidated.
- Further research is needed to understand the pathogenesis and optimize management strategies for these conditions.
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