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Related Experiment Videos

Thrombelastography changes in pre-eclampsia and eclampsia

C E Orlikowski1, D A Rocke, W B Murray

  • 1Department of Anaesthetics, University of Natal, Durban, South Africa.

British Journal of Anaesthesia
|August 1, 1996
PubMed
Summary
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This study in 49 pre-eclampsia patients found strong correlations between thrombelastography (TEG) variables and platelet counts. Bleeding time did not correlate with platelet count or TEG, suggesting TEG is a better indicator of hemostasis in these patients.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Clinical Pathology

Background:

  • Pre-eclampsia and eclampsia are serious conditions affecting pregnant individuals.
  • Thrombocytopenia (low platelet count) is a common complication.
  • Assessing hemostasis in these patients is crucial for management.

Purpose of the Study:

  • To investigate the correlation between platelet count, bleeding time, and thrombelastography (TEG) variables in pregnant patients with pre-eclampsia or eclampsia.
  • To determine the reliability of these tests in assessing hemostasis in this population.

Main Methods:

  • Collected data on platelet count, bleeding time, and TEG variables from 49 pregnant patients.
  • Analyzed correlations between these parameters, with specific focus on varying thresholds of platelet count (< or = 150 x 10(9)/L and < or = 100 x 10(9)/L).

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  • Evaluated the relationship between prolonged bleeding time, thrombocytopenia, and TEG results.

    • Main Results:

    • 37% of patients had platelet counts <= 150 x 10(9)/L, and 14% had counts <= 100 x 10(9)/L.
    • TEG variables (k time and maximum amplitude) showed strong correlations with platelet count (r = -0.68 to 0.78, P < 0.05).
    • Bleeding time did not correlate with platelet count or TEG variables, and normal TEG was observed in patients with prolonged bleeding time and adequate platelet counts.

    Conclusions:

    • TEG variables are strongly correlated with platelet count in pre-eclampsia/eclampsia, indicating their utility in assessing hemostasis.
    • Bleeding time is not a reliable indicator of hemostatic function in these patients.
    • A platelet count of 75 x 10(9)/L may be associated with adequate hemostasis, as suggested by TEG findings.