Related Experiment Videos
Delayed hypersensitivity reactions to corticosteroids applied to mucous membranes
A J Bircher1, F Pelloni, S Langauer Messmer
1Department of Dermatology, University Hospital, Basel, Switzerland.
The British Journal of Dermatology
|August 1, 1996
Summary
Newer corticosteroids like tixocortol pivalate and budesonide are increasingly linked to nasal mucosal contact sensitivity. Allergic reactions are rare on other mucosal surfaces and in the bronchial tree.
Area of Science:
- Dermatology
- Allergology
- Otorhinolaryngology
Background:
- Corticosteroids are widely used on mucosal surfaces, including the nose, eyes, and bronchial tree.
- Mucosal contact sensitivity to corticosteroids has historically been uncommon.
Observation:
- Since the introduction of tixocortol pivalate and budesonide, there has been a rise in reported cases of mucosal contact sensitivity.
- Nasal mucosa is the most frequently affected site.
Findings:
- Three cases of contact allergy to tixocortol pivalate or budesonide nasal sprays were observed.
- One case of allergic contact stomatitis due to tixocortol pivalate oral lozenges was reported.
Implications:
- Healthcare providers should be aware of the potential for contact allergy to newer corticosteroids.
- Further investigation into the prevalence and mechanisms of corticosteroid-induced mucosal contact sensitivity is warranted.