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Novel systems for controlled delivery of macromolecules
1Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Critical Reviews in Eukaryotic Gene Expression
|January 1, 1996
Summary
Synthetic polymers offer a promising method for delivering gene therapy agents. This review explores their use in controlled protein delivery and potential applications for gene transfer, advancing new human disease treatments.
Area of Science:
- Biotechnology
- Polymer Science
- Gene Therapy
Background:
- Gene therapy aims to treat diseases by modifying tissue DNA.
- Efficient and stable gene delivery to target cells is crucial for therapeutic success.
- Synthetic polymers are established for controlled drug and macromolecule delivery.
Purpose of the Study:
- To review the application of polymers in controlled protein delivery.
- To explore the potential of polymer delivery systems for gene transfer agents.
Main Methods:
- Literature review of polymer applications in controlled delivery.
- Analysis of polymer properties relevant to macromolecule and gene delivery.
Main Results:
- Polymers have a proven track record in controlled protein delivery.
- The principles of controlled macromolecule delivery by polymers are applicable to gene transfer.
Conclusions:
- Polymer-based systems show significant potential for advancing gene therapy delivery.
- Further research into polymer-gene transfer agent interactions is warranted.