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Bioactive steroidal alkaloids from Solanum umbelliferum
Y C Kim1, Q M Che, A A Gunatilaka
1Department of Chemistry, Virginia Polytechnic Institute, Blacksburg 24061-0212, USA.
Journal of Natural Products
|March 1, 1996
Abstract:
Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-beta-D- glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.