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A new prenylated flavonol from the root of Petalostemon purpureus
L Huang1, F Fullas, R J McGivney
1Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA.
Journal of Natural Products
|March 1, 1996
Abstract:
A new prenylated flavonol, petalopurpurenol (1), and a known dihydroflavonol, petalostemumol (2), have been isolated by DNA scission-guided fractionation of the organic portion of a 20% MeOH/CHCl3/H2O partition of a 50% MeOH/CHCl3 extract of the roots of Petalostemon purpureus. Compound 2 displayed moderate activity in DNA-scission assay. Both compounds 1 and 2 were evaluated for cytotoxicity in a panel of human cancer cell lines. The structures of petalopurpurenol (1) and petalostemumol (2) were determined by spectroscopic analysis.