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[Asthma and cyclic neutropenia]

A N Salazar Cabrera1, R Berrón Pérez, J A Ortega Martell

  • 1Departamento de Inmunología Clínica, Instituto Nacional de Pediatría, México.

Allergologia Et Immunopathologia
|January 1, 1996
PubMed
Summary

This case study details a patient with cyclic neutropenia experiencing recurrent infections, asthma, and oral aphtous disease. Treatment improved asthma and oral aphtous disease but not neutrophil counts, suggesting a complex interplay.

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Area of Science:

  • Immunology
  • Hematology
  • Allergy and Clinical Immunology

Background:

  • Cyclic neutropenia is a rare disorder characterized by periodic drops in neutrophil counts, increasing susceptibility to infections.
  • Recurrent oral aphtous disease (ROAD), asthma, and allergic rhinitis are common conditions that can significantly impact quality of life.

Observation:

  • A male patient presented with a history of recurrent infections since infancy, diagnosed with cyclic neutropenia at age 3.
  • At age 6, he developed episodic asthma and allergic rhinitis, followed by recurrent oral aphtous disease (ROAD) and asthma exacerbations at age 16.
  • During exacerbations, neutrophil counts dropped cyclically, while eosinophil counts and IgE levels increased significantly.

Findings:

  • Specific immunotherapy and timomodulin therapy led to clinical improvement in asthma and resolution of ROAD.

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  • Despite clinical improvements, cyclic neutropenia persisted, indicating a complex relationship between the conditions.
  • The case highlights a potential physiopathological link between cyclic neutropenia, allergic diseases, and recurrent oral aphtous disease.

    • Implications:

    • This case may offer insights into the pathogenesis of asthma and recurrent oral aphtous disease (ROAD) in the context of immune dysregulation.
    • Understanding such rare associations can guide future research into the complex interplay of hematological and immunological disorders.
    • Further investigation is warranted to elucidate the underlying mechanisms connecting cyclic neutropenia with allergic and autoimmune conditions.