Comparison of treatment modalities for squamous cell carcinoma

Numerous treatment modalities exist for cutaneous SCC. Having a variety of modalities in our armamentarium is useful, but they should be selected carefully based on certain key clinical and histologic prognostic factors. The histologic parameters should be provided to you by your dermatopathologist and can direct the clinician to better tailor treatment to specific neoplasms and thus produce more predictable outcomes. By incorporating the available prognostic factors in the literature, we can develop a reproducible schema or algorithmic approach to the treatment of cutaneous SCC to provide the highest cure rates possible while minimizing the morbidity for our patients (see Table 1).