Related Experiment Videos
Structure and in vivo activity of hypoglycaemic analogues of human growth hormone (6-13)
1Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
Drug Design and Discovery
|August 1, 1995
Abstract:
A range of peptide analogues related to Asu11-human growth hormone (6-13) have been synthesized and tested for hypoglycaemic activity using in vivo insulin tolerance tests. Utilising an alanine scan procedure and a selective amino acid residue approach these structure-activity studies suggest that residues Phe10, Arg8 and the C-terminal beta-turn structure are important for the expression of biological activity.