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New synthetic strategy for the synthesis of 24-epibrassinolide
1Department of Organic Chemistry, C.E.T.S. Institut Químic de Sarrià, Universitat Ramon Llull, Barcelona, Spain.
Steroids
|September 1, 1996
Abstract:
The synthesis of (22E,24R)-5 alpha-ergosta-2,22-dien-6-one (2), a key intermediate to the preparation of 24-epibrassinolide (1), was achieved through the 3,6-diketone 8 in a 40% overall yield in five steps starting from ergosterol (3).