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Left ventricular function in scleroderma

G P Armstrong1, G A Whalley, R N Doughty

  • 1Department of Medicine, University of Auckland, New Zealand.

British Journal of Rheumatology
|October 1, 1996
PubMed
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Scleroderma patients show abnormal diastolic function, indicated by an enlarged left atrium and prolonged mitral deceleration time. This dysfunction correlates with Raynaud's phenomenon duration, suggesting primary myocardial involvement.

Area of Science:

  • Cardiology
  • Rheumatology
  • Internal Medicine

Background:

  • Scleroderma can impact the heart directly and indirectly through hypertension.
  • Left ventricular function in scleroderma requires further investigation.

Purpose of the Study:

  • To evaluate left heart function in scleroderma patients using echocardiography.
  • To identify potential predictors of cardiac dysfunction in scleroderma.

Main Methods:

  • Transthoracic echocardiography was performed on 35 scleroderma patients and matched controls.
  • Analysis included left ventricular dimensions, mass, systolic function, and diastolic parameters.
  • Statistical analysis adjusted for confounders like Raynaud's duration and hypertension.

Main Results:

Related Experiment Videos

  • Scleroderma patients had significantly enlarged left atria and prolonged mitral deceleration times compared to controls.
  • No significant differences were observed in left ventricular size, wall thickness, or systolic function.
  • Raynaud's phenomenon duration independently predicted multiple diastolic function measures.

Conclusions:

  • Scleroderma is associated with abnormal left ventricular diastolic function, independent of hypertrophy or hypertension.
  • Primary myocardial involvement in scleroderma may cause diastolic dysfunction.
  • Diastolic abnormalities correlate with the duration of Raynaud's phenomenon.