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Dyslipidemia in peripheral vascular disease
Current Opinion in Lipidology
|August 1, 1996
Summary
Peripheral atherosclerosis, affecting limbs, differs from coronary artery disease. Lipid metabolism changes, like reduced HDL and increased lipoprotein remnants, are key factors. Lipid-lowering therapy may even reverse plaque buildup.
Area of Science:
- Vascular biology and lipid metabolism.
Background:
- Peripheral atherosclerosis in carotid and aortofemoral arteries exhibits distinct features compared to coronary atherosclerosis.
- Lipid metabolism plays a crucial role in the development and progression of peripheral vascular diseases.
Purpose of the Study:
- To review recent research on the intricate relationship between peripheral atherosclerosis and lipid metabolism.
- To highlight specific lipid alterations observed in extracoronary atherosclerosis.
Main Methods:
- Review of recent scientific literature and intervention trials.
- Analysis of plasma lipid profiles, including lipoprotein remnants, lipoprotein (a), lipid peroxidation, and high-density lipoprotein (HDL) subfractions.
Main Results:
- Elevated plasma levels of lipoprotein remnants, lipoprotein (a), and lipid peroxidation parameters are associated with extracoronary atherosclerosis.
- Reduced levels of high-density lipoprotein (HDL) and its subfractions are observed.
- Coexisting conditions like smoking and diabetes can influence these lipid modifications.
Conclusions:
- Plasma lipoprotein patterns are significant determinants of peripheral vascular lesions.
- Hypolipidemic therapy has shown potential in regressing established atherosclerotic plaques, emphasizing the role of lipid management.