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A randomized comparison of iodixanol and iohexol in adult intracranial computed tomography scanning
1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Rationale And Objectives:
Nonionic iodinated contrast media have proved effective for computed tomography (CT) of the head and have demonstrated greater tolerability than their ionic counterparts. Iodixanol is a new nonionic agent with the added attribute of being isosmolar to blood and having less than half the osmolality of iohexol. Phase I safety, tolerance, and pharmacokinetic studies have indicated that iodixanol may be associated with fewer adverse effects than iohexol while providing equivalent diagnostic information.
Methods:
We compared the safety and efficacy of iodixanol at 270 mg I/ ml (IOD-270) and at 320 mg I/ml (IOD-320) with iohexol 300 mg I/ml (IOH-300).
Results:
No statistically significant differences in the quality of images or in the occurrence of adverse events were found among the three treatment groups. Pairwise comparisons of injection-associated discomfort revealed that significantly more patients in the IOH-300 group experienced discomfort than in either the IOD-270 or IOD-320 groups.
Conclusion:
Iodixanol at 270 or 320 mg I/ml was found to be safe and effective when administered intravenously at a volume of 100 ml for intracranial CT scans in adult patients.